Diastereoselective radical mediated alkylation of a chiral glycolic acid derivative.
نویسندگان
چکیده
Radical alkylation of 2-(tert-butyl)-2-methyldioxolan-4-one, a chiral equivalent of glycolic acid, occurs with good to high diastereoselectivity that compares favorably with the corresponding enolate alkylation. The importance of the position of the transition state position, early or late, is highlighted.
منابع مشابه
Diastereoselective radical addition to γ-alkyl-α-methylene-γ-butyrolactams and the synthesis of a chiral pyroglutamic acid derivative
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 16 شماره
صفحات -
تاریخ انتشار 2011